Protease
Last updated: February 11, 2026
Table of Contents
Quick Summary
Protease A digestive enzyme that breaks down proteins into amino acids and smaller peptides for absorption. Commonly added to digestive supplements.
What It Is
A digestive enzyme that breaks down proteins into amino acids and smaller peptides for absorption. Commonly added to digestive supplements.
Compare to Similar Ingredients
- vs. bromelain: Both are protein-digesting enzymes. Protease is a general term for any protein-breaking enzyme (often microbial), while bromelain is a specific protease from pineapple with anti-inflammatory properties.
- vs. papain: Both are proteolytic enzymes that break down proteins. Protease is a broad category (often from bacteria/fungi), while papain is a specific plant protease from papaya.
Why It's Used in Dog Products
Manufacturers include protease in dog food, treats, and supplements for several reasons:
- Helps break down dietary proteins
- May reduce protein-related digestive upset
- Supports nutrient absorption
- Can benefit dogs with exocrine pancreatic insufficiency (EPI)
Quality Considerations
When evaluating protease in dog products, it's important to understand clinical evidence, appropriate dosing, and targeted health benefits. This ingredient's quality and appropriateness can vary significantly based on sourcing, processing, and the specific formula it's used in.
Dogs naturally produce proteases (trypsin, pepsin), but supplementation may help dogs with digestive disorders or those transitioning to higher-protein diets. Quality depends on enzyme activity units (HUT - Hemoglobin Unit Tyrosine).
Potential Concerns
While protease can be appropriate in dog nutrition, pet owners should be aware of efficacy, quality of source material, and potential interactions with medications. Individual dogs may respond differently to the same ingredient based on their health status, age, and sensitivities.
Valuable digestive enzyme for dogs with protein digestion issues or pancreatic conditions. Most beneficial when combined with other digestive enzymes in a full-spectrum formula.
Frequently Asked Questions
Is protease safe for dogs?
Yes, protease is safe for dogs when used appropriately in properly formulated dog food. As with any ingredient, individual dogs may have sensitivities, so monitor for any adverse reactions when first introducing products containing this ingredient.
What does protease do in dog products?
A digestive enzyme that breaks down proteins into amino acids and smaller peptides for absorption. Commonly added to digestive supplements. Dog food manufacturers include this ingredient to provide helps break down dietary proteins and provide may reduce protein-related digestive upset.
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